Background: To compare the lamina cribrosa between eyes with and without neovascular glaucoma (NVG) using\nenhanced depth imaging spectral-domain optical coherence tomography.\nMethods: Forty-six patients with proliferative diabetic retinopathy were enrolled in this cross-sectional study. The\npatients were divided into two groups based on the absence or presence of NVG (the non-NVG group and the\nNVG group, respectively). The intraocular pressure (IOP), circumpapillary retinal nerve fiber layer (cpRNFL) thickness,\nanterior lamina cribrosa depth (ALD), and laminar thickness (LT) were compared between the groups.\nResults: In the non-NVG group, the mean age was 66.2 �± 2.4 (mean �± standard error) years, mean maximum IOP\nwas 18.8 �± 1.8 mmHg, mean cpRNFL thickness was 91.2 �± 3.9 �¼m, mean ALD was 407.0 �± 22.9 �¼m, and mean LT\nwas 155.0 �± 4.7 �¼m. In the NVG group, the mean age was 61.4 �± 2.1 years, mean maximum IOP was 33.1 �± 1.\n6 mmHg, mean cpRNFL thickness was 73.6 �± 3.4 �¼m, mean ALD was 403.9 �± 20.1 �¼m, and mean LT was 156.9 �± 4.\n2 �¼m. The IOP was significantly higher and the cpRNFL was significantly thinner in the NVG group (P < 0.001 and\nP = 0.002, respectively). However, the age, ALD, and LT were not statistically different between the groups (P = 0.\n151, 0.919, and 0.757, respectively).\nConclusions: Although the cpRNFL was thinner, the structure of the lamina cribrosa was unchanged in the NVG\neyes. Axonal loss of the retinal ganglion cells in NVG patients was prior to lamina cribrosa deformation.
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